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Mary Isabel McCracken was born on December 27, 1865 in Oakland, California to John Harvey McCracken and Mary “Bridget” Dolan McCracken. Her father was born in Ohio in 1828, moved to California in 1852, and worked as a carpenter. Her mother was born in Ireland in 1835, immigrated to the United States in 1852, and worked in the home. John and Bridget were married in Alameda in 1862 and owned a farm in Brooklyn Township, which is now East Oakland. They had seven children; Isabel had an older sister, three younger sisters, and two younger brothers. All seven of the McCracken children lived well into adulthood. Catherine was a census enumerator, Emma was a schoolteacher, Augusta was a math teacher in the Oakland public schools, John was the manager of a lumberyard, and William was a dentist, a representative of District 4 on the Oakland city council for sixteen years, and the 38th mayor of Oakland, from 1933 to 1941.